Background: Spontaneous pneumomediastinum (PM) is a rare benign disease entity in children with several predisposing factors. This study reports a case of spontaneous PM related to the use of electronic cigarettes (e-cigarettes) in a 17-year-old adolescent. Case Presentation: A 17-year-old male. user of e-cigarettes. https://parisnaturalfoodes.shop/product-category/application-kit/